PREDICTION OF PROGRESSION OF ATHEROSCLEROSIS IN PATIENTS WITH TYPE 2 DIABETES MELLITUS AND CHRONIC PANCREATITIS

The aim of the research was to study relationship between level vaspin and thickness intima-media carotid artery (CIMT), parameters carbohydrate lipid metabolism, functional state pancreas, markers inflammation, create a mathematical model for progression atherosclerosis in patients with type 2 diabetes mellitus (DM-2) chronic pancreatitis (CP).
 Materials methods: Serum 114 people DM-2 or CP combination these diseases were obtained. inflammation status pancreas studied. CIMT measured by means B-mode ultrasonography. obtained data processed methods non-parametric statistics dependence on group, questions statistical significance differences two unrelated groups, tightness analyzed parameters.
 Results: A statistically significant (p<0.05) increase serum levels compared other studied groups reliable correlation vaspin, metabolism obtained, it appeared be dependent presence comorbid pathology. value / tumor necrosis factor-α (TNF-α), starting from which is considered present, calculated.
 Conclusions: Undertaken confirmed positive connection insulin resistance markers, but also demonstrated that positively associated CIMT. predicting pathology developed. It Vaspin/TNF-α ratio can used as marker early atherosclerotic lesion vascular wall, indicating role atherogenesis